SCHEMBL6994869

SCHEMBL6994869

c1ccc(COc2ccc(Nc3ncnc4cnc(NCC5CCCO5)nc34)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 4/20 0.51
ALDH1A1 P00352 4/20 0.51
MAPT P10636 3/20 0.51
RECQL P46063 2/20 0.51
BLM P54132 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
HTT P42858 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
NPC1 O15118 2/20 0.51
GLA P06280 1/20 0.51
KMT2A Q03164 1/20 0.51
KCNH3 Q9ULD8 1/20 0.48
EGFR P00533 5/20 0.48
ERBB2 P04626 4/20 0.48
CHEK2 O96017 1/20 0.48
ROS1 P08922 1/20 0.48
FLT3 P36888 1/20 0.48
ERBB4 Q15303 1/20 0.48
AURKB Q96GD4 1/20 0.48
CLK4 Q9HAZ1 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8317434 0.80 EPHA2 (0.53) HTTSMN1; SMN2NPC1KMT2AEGFR
SCHEMBL6999415 0.79 EGFR (0.55) MAPTHTTNPC1KMT2AEGFR
SCHEMBL8319425 0.79 MAPT (0.56) MAPK1ALDH1A1MAPTRECQLHTT
SCHEMBL8317410 0.79 EGFR (0.62) KCNH3EGFRBRAFTNK2CSNK2A1
SCHEMBL6994082 0.79 EGFR (0.51) MAPTHTTNPC1KMT2AEGFR
SCHEMBL8315088 0.79 EGFR (0.62) ALDH1A1KCNH3EGFRBRAFGAA
SCHEMBL6994075 0.79 EGFR (0.51) MAPTHTTNPC1KMT2AEGFR
SCHEMBL8316924 0.79 CSNK2A1 (0.65) MAPK1MAPTRECQLKMT2AKCNH3
SCHEMBL8316693 0.78 EGFR (0.59) MAPTHTTSMN1; SMN2NPC1KMT2A
SCHEMBL8321243 0.76 MAPT (0.52) MAPK1MAPTNPSR1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888351-B1 PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION THOMAE GMBH DR K (DE) 2003-10-15 EP disclosed
EP-0888351-A1 PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION Dr. Karl Thomae GmbH (DE) 1999-01-07 EP disclosed
WO-1997032880-A1 PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION DR. KARL THOMAE GMBH (DE) 1997-09-12 WO disclosed