Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319425 | 0.89 | MAPT (0.56) | EGFRCSNK2A1BRAFKCNH3 | |
| SCHEMBL8315088 | 0.89 | EGFR (0.62) | EGFRCSNK2A1BRAFKCNH3TNK2 | |
| SCHEMBL8316924 | 0.87 | CSNK2A1 (0.65) | EGFRCSNK2A1BRAFKCNH3 | |
| SCHEMBL8321243 | 0.85 | MAPT (0.52) | EGFRCSNK2A1BRAF | |
| SCHEMBL8317434 | 0.84 | EPHA2 (0.53) | EGFRCSNK2A1BRAFTNK2 | |
| SCHEMBL8316693 | 0.82 | EGFR (0.59) | EGFRBRAFKCNH3TNK2 | |
| SCHEMBL6994869 | 0.79 | MAPK1 (0.51) | EGFRCSNK2A1BRAFKCNH3TNK2 | |
| SCHEMBL8316032 | 0.78 | EGFR (0.72) | EGFR | |
| SCHEMBL8317824 | 0.78 | EGFR (0.66) | EGFR | |
| SCHEMBL8315545 | 0.77 | EGFR (0.72) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |