Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 10/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316693 | 0.92 | EGFR (0.59) | EPHA2KDRBRAFTNK2EGFR | |
| SCHEMBL8319425 | 0.88 | MAPT (0.56) | BRAFEGFRHPGDHTTCSNK2A1 | |
| SCHEMBL8317410 | 0.84 | EGFR (0.62) | BRAFTNK2EGFRCSNK2A1 | |
| SCHEMBL8315088 | 0.84 | EGFR (0.62) | BRAFTNK2EGFRHPGDCSNK2A1 | |
| SCHEMBL8316924 | 0.82 | CSNK2A1 (0.65) | BRAFEGFRCSNK2A1LMNAKMT2A | |
| SCHEMBL8321243 | 0.81 | MAPT (0.52) | BRAFEGFRHTTCSNK2A1LMNA | |
| SCHEMBL6994869 | 0.80 | MAPK1 (0.51) | BRAFTNK2EGFRERBB2HTT | |
| SCHEMBL8316240 | 0.78 | EGFR (0.69) | EPHA2KDRBRAFEGFRHPGD | |
| SCHEMBL8314200 | 0.78 | EGFR (0.64) | BRAFEGFRHPGDERBB2HTT | |
| SCHEMBL8317784 | 0.76 | EGFR (0.49) | EGFRHPGDERBB2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |