SCHEMBL6995090

SCHEMBL6995090

CCN1CCC(O)(c2ccc(Cl)c(Cl)c2)C(C(=O)c2ccc(Cl)c(Cl)c2)C1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 6/20 0.74
KMT2A Q03164 6/20 0.51
ALDH1A1 P00352 6/20 0.51
LMNA P02545 4/20 0.51
MAPT P10636 3/20 0.51
MEN1 O00255 1/20 0.49
MAPK1 P28482 1/20 0.49
KDM2B Q8NHM5 1/20 0.46
HPGD P15428 1/20 0.43
DUSP3 P51452 1/20 0.43
PTPN5 P54829 1/20 0.43
PTPN11 Q06124 1/20 0.43
DRD2 P14416 1/20 0.42
SLC6A4 P31645 3/20 0.42
CYP2D6 P10635 2/20 0.42
SLC6A2 P23975 2/20 0.42
KCNH2 Q12809 2/20 0.42
CYP1A1 P04798 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4194116 0.85 SLC6A3 (1.00) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL7001081 0.84 KMT2A (0.72) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL6995927 0.83 SLC6A3 (0.66) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL6998218 0.82 SLC6A3 (0.64) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL7004826 0.80 KMT2A (0.60) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL14081616 0.79 KMT2A (0.72) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL11746033 0.76 KMT2A (0.78) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL10107795 0.76 KMT2A (0.66) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL7002087 0.74 SLC6A3 (0.79) SLC6A3KMT2AALDH1A1LMNAMAPT
SCHEMBL7001403 0.72 SLC6A3 (0.78) SLC6A3KMT2AALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1242080-A4 DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE UNIV GEORGETOWN (US) 2003-01-22 EP claimed
EP-1242080-A1 DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE GEORGETOWN UNIVERSITY (US) 2002-09-25 EP claimed
WO-2001022964-A1 DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE GEORGETOWN UNIVERSITY (US) 2001-04-05 WO claimed
EP-1242080-A4 DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE UNIV GEORGETOWN (US) 2003-01-22 EP disclosed
EP-1242080-A1 DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE GEORGETOWN UNIVERSITY (US) 2002-09-25 EP disclosed
WO-2001022964-A1 DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE GEORGETOWN UNIVERSITY (US) 2001-04-05 WO disclosed