SCHEMBL6995141

SCHEMBL6995141

C[C](C)C(=O)CC(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.32
LMNA P02545 1/20 0.32
ALOX15 P16050 1/20 0.32
BLM P54132 1/20 0.32
PMP22 Q01453 1/20 0.32
CA4 P22748 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4444683 0.82 CES1 (0.36) CA1CA4
SCHEMBL11352444 0.78 TDP1 (0.35)
SCHEMBL31203280 0.77 LDHA (0.33) BLMCA4
SCHEMBL123396 0.75
SCHEMBL23927231 0.73 CA4 (0.32) CA4
SCHEMBL3230536 0.73 OR51E2 (0.40) CA4
SCHEMBL6988837 0.72 CES1 (0.33)
SCHEMBL2392558 0.71 CA4 (0.36) CA4
Acetic Acid SCHEMBL288009 0.71 HMGCR (0.46) LMNA
Fluoride SCHEMBL23927232 0.71 OR51E2 (0.38) CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0931082-B1 NODULISPORIC ACID DERIVATIVES MERCK & CO INC (US) 2003-03-19 EP claimed
US-6221894-B1 ACARICIDAL, ANTIPARASITIC, INSECTICIDAL AND ANTHELMINTIC AGENTS. MERCK & CO., INC. 2001-04-24 US claimed
EP-0931082-B1 NODULISPORIC ACID DERIVATIVES MERCK & CO INC (US) 2003-03-19 EP disclosed