Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995149 | 0.94 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP1A2ALDH1A1ARCYP3A4 | |
| SCHEMBL7000260 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP1A2ALDH1A1ARCYP3A4 | |
| SCHEMBL6996820 | 0.91 | ALDH1A1 (0.43) | SMN1; SMN2CYP1A2ALDH1A1ARLMNA | |
| SCHEMBL7002027 | 0.90 | ALDH1A1 (0.44) | SMN1; SMN2CYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL6995982 | 0.89 | MAPT (0.47) | SMN1; SMN2CYP1A2ALDH1A1LMNAMEN1 | |
| SCHEMBL7000021 | 0.85 | KDM4E (0.41) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| Potassium Ion SCHEMBL7823785 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6996815 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2CYP1A2ALDH1A1LMNAMEN1 | |
| SCHEMBL25397001 | 0.82 | MEN1 (0.50) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7002020 | 0.82 | ALDH1A1 (0.46) | SMN1; SMN2CYP1A2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |