Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002027 | 0.93 | ALDH1A1 (0.44) | ALDH1A1DCTPP1GAARAB9ANPSR1 | |
| SCHEMBL25397001 | 0.88 | MEN1 (0.50) | ALDH1A1DCTPP1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL6995149 | 0.88 | SMN1; SMN2 (0.52) | ALDH1A1DCTPP1GAASMN1; SMN2CYP1A2 | |
| SCHEMBL6996815 | 0.87 | ALDH1A1 (0.44) | ALDH1A1DCTPP1GAARAB9ASMN1; SMN2 | |
| SCHEMBL6995156 | 0.82 | SMN1; SMN2 (0.51) | ALDH1A1GAASMN1; SMN2CYP1A2MAPT | |
| SCHEMBL6999206 | 0.81 | CYP1A2 (0.47) | GAARAB9ASMN1; SMN2CYP1A2PDE4A | |
| SCHEMBL6995979 | 0.81 | MAPT (0.48) | ALDH1A1SMN1; SMN2CYP1A2MAPK1MAPT | |
| SCHEMBL7000260 | 0.80 | SMN1; SMN2 (0.52) | ALDH1A1DCTPP1GAASMN1; SMN2CYP1A2 | |
| SCHEMBL6996820 | 0.80 | ALDH1A1 (0.43) | ALDH1A1DCTPP1GAARAB9ASMN1; SMN2 | |
| SCHEMBL6999211 | 0.77 | CYP1A2 (0.48) | ALDH1A1GAARAB9ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |