SCHEMBL6995401

SCHEMBL6995401

N#CN/C(=N\Cc1ccncc1)N1CCC(=C2c3ccc(Cl)cc3SCc3cccnc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 20/20 1.00
FNTB P49356 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6995404 1.00 FNTA (1.00) FNTAFNTB
SCHEMBL6995930 0.87 FNTA (0.77) FNTAFNTB
SCHEMBL6995933 0.87 FNTA (0.77) FNTAFNTB
SCHEMBL6995407 0.86 FNTA (0.75) FNTAFNTB
SCHEMBL6991647 0.81 FNTA (1.00) FNTAFNTB
SCHEMBL9214088 0.80 FNTA (0.75) FNTAFNTB
SCHEMBL6995047 0.79 FNTA (0.66) FNTAFNTB
SCHEMBL6995055 0.79 FNTA (0.66) FNTAFNTB
SCHEMBL6993788 0.79 FNTA (0.65) FNTAFNTB
SCHEMBL6993792 0.79 FNTA (0.65) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1021448-B1 TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS SCHERING CORP (US) 2003-05-02 EP claimed
US-6130229-A Tricyclic compounds having activity as RAS-FPT inhibitors SCHERING CORPORATION (US) 2000-10-10 US claimed
EP-1021448-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS SCHERING CORPORATION (US) 2000-07-26 EP claimed
WO-1998015556-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS SCHERING CORPORATION (US) 1998-04-16 WO claimed
EP-1021448-B1 TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS SCHERING CORP (US) 2003-05-02 EP disclosed
US-6130229-A Tricyclic compounds having activity as RAS-FPT inhibitors SCHERING CORPORATION (US) 2000-10-10 US disclosed
EP-1021448-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS SCHERING CORPORATION (US) 2000-07-26 EP disclosed
WO-1998015556-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS SCHERING CORPORATION (US) 1998-04-16 WO disclosed