Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27761216 | 0.90 | NOTUM (0.57) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL27465095 | 0.87 | SMN1; SMN2 (0.57) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL4688756 | 0.85 | SMN1; SMN2 (0.56) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL20869536 | 0.84 | NOTUM (0.53) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL29997798 | 0.81 | SMN1; SMN2 (0.51) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL11551815 | 0.81 | SMN1; SMN2 (0.51) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL8471853 | 0.81 | NOTUM (0.49) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL28965840 | 0.78 | TSHR (0.50) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL4983966 | 0.77 | NOTUM (0.47) | NOTUMSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL27652751 | 0.77 | KMT2A (0.53) | NOTUMSMN1; SMN2TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105934246-B | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2019-10-22 | — | — | CN | claimed |
| CN-105934246-A | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2016-09-07 | — | — | CN | claimed |
| CN-105934246-B | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-105934246-A | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2016-09-07 | — | — | CN | disclosed |
| EP-1345930-A2 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050067-A2 | PHARMACEUTICAL HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |