Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.37 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.37 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350957 | 0.83 | TSHR (0.46) | MAPTALDH1A1INMTLMNA | |
| SCHEMBL2865650 | 0.77 | CYP2D6 (0.50) | ACEKMT2ACYP2D6CYP2C19POLB | |
| SCHEMBL4276458 | 0.74 | KMT2A (0.46) | ACEKMT2ACYP2D6CYP2C19POLB | |
| SCHEMBL1590233 | 0.74 | INMT (0.57) | ACEKMT2ACYP2D6CYP2C19POLB | |
| SCHEMBL4968832 | 0.72 | ALDH1A1 (0.49) | KMT2AMEN1USP2ALDH1A1L3MBTL1 | |
| SCHEMBL1219320 | 0.71 | — | — | |
| SCHEMBL17377709 | 0.69 | ACE (0.42) | ACEKMT2ACYP2D6CYP2C19POLB | |
| SCHEMBL7572893 | 0.69 | — | — | |
| SCHEMBL3492650 | 0.68 | GAA (0.54) | ACEKMT2ACYP2D6CYP2C19POLB | |
| SCHEMBL19962102 | 0.68 | CYP2D6 (0.66) | ACEKMT2ACYP2D6CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719779-B1 | SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE | EISAI CO LTD (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-6051705-A | HAVING INHIBITORY ACTIVITY AGAINST ANGIOTENSIN I CONVERTING ENZYME AND NEUTRAL ENDPEPTIDASE | EISAI CO., LTD. (JP) | 2000-04-18 | — | — | US | disclosed |
| US-5789403-A | PEPTIDASE AND ACE ENZYME INHIBITORS | EISAI CO., LTD. (JP) | 1998-08-04 | — | — | US | disclosed |
| EP-0719779-A1 | SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE | Eisai Co., Ltd. (JP) | 1996-07-03 | — | — | EP | disclosed |