Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.60 |
| ▸ | SRC | P12931 | 16/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | BCR | P11274 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453074 | 0.88 | MAP2K1 (0.78) | MAP2K1SRCFYNABL1BCR | |
| SCHEMBL6383464 | 0.80 | SRC (0.64) | SRCFYNABL1BCR | |
| SCHEMBL5254607 | 0.79 | SRC (0.72) | MAP2K1SRCFYNABL1BCR | |
| SCHEMBL6380685 | 0.79 | SRC (0.61) | MAP2K1SRCFYNABL1BCR | |
| SCHEMBL6382264 | 0.79 | EGFR (0.57) | MAP2K1SRCFYNABL1BCR | |
| SCHEMBL5254265 | 0.78 | SRC (0.69) | SRCFYNABL1BCR | |
| SCHEMBL6380678 | 0.78 | SRC (0.54) | MAP2K1SRCFYNABL1BCR | |
| SCHEMBL6993524 | 0.77 | MAP2K1 (0.76) | MAP2K1IGF1R | |
| SCHEMBL6997884 | 0.77 | MAP2K1 (0.63) | MAP2K1SRCIGF1R | |
| SCHEMBL6183013 | 0.77 | SRC (0.73) | MAP2K1SRCFYNABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |