Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24489005 | 0.83 | ALDH1A1 (0.62) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL24489088 | 0.82 | ALDH1A1 (0.67) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL7057301 | 0.82 | MAPT (0.72) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL5096639 | 0.81 | ALDH1A1 (0.73) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL24489002 | 0.81 | ALDH1A1 (0.65) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL24489102 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL7142901 | 0.79 | ALDH1A1 (0.63) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL24489106 | 0.78 | ALDH1A1 (0.76) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL7003377 | 0.78 | ALDH1A1 (0.80) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL24489136 | 0.78 | MAPT (0.62) | ALDH1A1MAPTKDM4EHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |