Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.57 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998377 | 0.92 | ADORA3 (0.54) | PKN1PKN2ADORA3GAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7001387 | 0.90 | ADORA3 (0.53) | PKN1PKN2ADORA3GAAALDH1A1 | |
| SCHEMBL4888425 | 0.88 | PKN1 (0.55) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL3947018 | 0.88 | PKN1 (0.55) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL15228495 | 0.88 | PKN1 (0.55) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL8598342 | 0.88 | GAA (0.56) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL8328888 | 0.87 | PKN1 (0.51) | PKN1PKN2ADORA3GAAMGAM | |
| Hydrochloric Acid SCHEMBL4882337 | 0.86 | PKN1 (0.53) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL7479338 | 0.85 | PKN1 (0.52) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL7486947 | 0.85 | PKN1 (0.52) | PKN1PKN2ADORA3GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | claimed |
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | disclosed |
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | disclosed |
| EP-1189889-A1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | Elan Pharma International Limited (IE) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000075117-A1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2000-12-14 | — | — | WO | disclosed |