Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31433394 | 0.84 | ALDH1A1 (0.50) | HDAC1HDAC6NPC1RAB9AHDAC3 | |
| SCHEMBL27621463 | 0.82 | ALDH1A1 (0.52) | EPHX2PLK1HDAC1HDAC6NPC1 | |
| SCHEMBL10153931 | 0.81 | PLK1 (0.70) | EPHX2PLK1HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL1364607 | 0.78 | MPO (0.61) | EPHX2HDAC6HDAC3NCOR2ALDH1A1 | |
| SCHEMBL20424311 | 0.78 | HDAC6 (0.67) | HDAC1HDAC6HDAC3NCOR2HDAC8 | |
| SCHEMBL6993793 | 0.78 | TSHR (0.60) | RAB9AALDH1A1SMN1; SMN2TP53KMT2A | |
| Ammonia Solution, Strong SCHEMBL11061336 | 0.78 | TSHR (0.60) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14359901 | 0.77 | EPHX2 (0.50) | EPHX2PLK1HDAC1HDAC6NPC1 | |
| SCHEMBL18837905 | 0.76 | PLK1 (0.63) | EPHX2PLK1HDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL10788701 | 0.76 | PLK1 (0.50) | EPHX2PLK1HDAC1HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874809-B1 | CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-27 | — | — | EP | disclosed |
| US-6239175-B1 | Carbamoyloxy derivatives of mutiline and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-29 | — | — | US | disclosed |
| US-6020368-A | MICROBIOCIDES | HINKS JEREMY DAVID (US) | 2000-02-01 | — | — | US | disclosed |