Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 17/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 17/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000849 | 0.99 | GABRG2 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6998651 | 0.91 | GABRG2 (0.42) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6998547 | 0.90 | GABRG2 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6994991 | 0.89 | GABRG2 (0.47) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657906 | 0.88 | GABRA1 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7000853 | 0.83 | GABRG2 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657940 | 0.80 | GABRG2 (0.53) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658778 | 0.80 | GABRG2 (0.37) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7000068 | 0.80 | GABRG2 (0.36) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658337 | 0.80 | GABRG2 (0.43) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212324-B1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-10-29 | — | — | EP | claimed |
| US-6608062-B1 | Ligands for gamma-aminobutyric acid receptors; treatment and/or prevention of central nervous system disorders, including anxiety | MERCK SHARP & DOHME LTD. | 2003-08-19 | — | — | US | claimed |
| EP-1212324-B1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-10-29 | — | — | EP | disclosed |
| US-6608062-B1 | Ligands for gamma-aminobutyric acid receptors; treatment and/or prevention of central nervous system disorders, including anxiety | MERCK SHARP & DOHME LTD. | 2003-08-19 | — | — | US | disclosed |