Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999283 | 0.90 | PTGS2 (0.33) | PTGS2PTGS1PGRAKR1C3AKR1C2 | |
| SCHEMBL6995715 | 0.90 | PTGS2 (0.43) | PTGS2PTGS1AKR1C3AKR1C2PDE3B | |
| SCHEMBL6996397 | 0.89 | GSK3B (0.43) | PTGS2PTGS1PGRAKR1C3AKR1C2 | |
| SCHEMBL7001438 | 0.89 | PTGS2 (0.39) | PTGS2PTGS1PGRPDE3BPDE3A | |
| SCHEMBL6997325 | 0.87 | PTGS2 (0.36) | PTGS2PTGS1PGRAKR1C3AKR1C2 | |
| SCHEMBL7002103 | 0.87 | AKR1C3 (0.38) | PTGS1PGRAKR1C3AKR1C2 | |
| SCHEMBL6998165 | 0.86 | PTGS2 (0.36) | PTGS2PTGS1PGRAKR1C3AKR1C2 | |
| SCHEMBL6997433 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1PGR | |
| SCHEMBL7000928 | 0.86 | BRAF (0.35) | PTGS2PTGS1PGRPDE3BPDE3A | |
| SCHEMBL7000841 | 0.84 | BRAF (0.35) | PTGS2PTGS1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |
| EP-1109799-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000061571-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2000-10-19 | — | — | WO | disclosed |