Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996567 | 0.87 | PTGS2 (0.40) | AKR1C3AKR1C2PTGS1PGR | |
| SCHEMBL6997650 | 0.86 | PTGS2 (0.38) | PTGS1CTSDBACE1NOTUMPGR | |
| SCHEMBL6995715 | 0.86 | PTGS2 (0.43) | AKR1C3AKR1C2PTGS1 | |
| SCHEMBL6996397 | 0.85 | GSK3B (0.43) | AKR1C3AKR1C2PTGS1PGR | |
| SCHEMBL6997353 | 0.82 | PTGS2 (0.43) | AKR1C3AKR1C2PTGS1 | |
| SCHEMBL6997443 | 0.82 | AKR1C3 (0.38) | AKR1C3AKR1C2PTGESPTGS1CTSD | |
| SCHEMBL6998165 | 0.82 | PTGS2 (0.36) | AKR1C3AKR1C2PTGS1PGR | |
| SCHEMBL7000249 | 0.82 | KDM4E (0.39) | AKR1C3AKR1C2PTGS1 | |
| SCHEMBL6999283 | 0.81 | PTGS2 (0.33) | AKR1C3AKR1C2PTGS1PGR | |
| SCHEMBL6997325 | 0.81 | PTGS2 (0.36) | AKR1C3AKR1C2PTGS1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |