Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20365826 | 0.68 | PRCP (0.48) | SMN1; SMN2PRCPOPRM1OPRK1 | |
| SCHEMBL4514045 | 0.67 | TSHR (0.44) | MAPTOPRM1 | |
| SCHEMBL4043644 | 0.67 | MAOA (0.46) | ALDH1A1PRCPHIF1A | |
| Hydrochloric Acid SCHEMBL3878664 | 0.66 | TSHR (0.47) | MAPTOPRM1 | |
| SCHEMBL6973916 | 0.65 | TP53 (0.41) | MAPT | |
| SCHEMBL14591478 | 0.63 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1PRCPMEN1 | |
| SCHEMBL6961228 | 0.62 | MTNR1B (0.41) | MAPT | |
| SCHEMBL6967120 | 0.61 | MTNR1B (0.42) | MAPT | |
| SCHEMBL15421539 | 0.61 | SMN1; SMN2 (0.70) | SMN1; SMN2MAPTALDH1A1PRCPMEN1 | |
| SCHEMBL27985631 | 0.61 | PRCP (0.60) | SMN1; SMN2ALDH1A1PRCPOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421824-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| EP-2421824-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |