Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | LTK | P29376 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31133143 | 0.89 | NPSR1 (0.43) | NPSR1ALDH1A1DAPK3PRKD3MAP4K4 | |
| SCHEMBL7004410 | 0.86 | NPSR1 (0.41) | NPSR1ALDH1A1DAPK3PRKD3MAP4K4 | |
| SCHEMBL11272207 | 0.79 | KDM4E (0.45) | ALDH1A1DAPK3PRKD3MAP4K4PRKACA | |
| SCHEMBL21057401 | 0.77 | CYP1A2 (0.36) | NPSR1ALDH1A1DAPK3PRKD3MAP4K4 | |
| SCHEMBL6994179 | 0.76 | MEN1 (0.49) | GAAKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL24275924 | 0.74 | IKBKB (0.40) | NPSR1ALDH1A1DAPK3PRKD3MAP4K4 | |
| SCHEMBL7522906 | 0.72 | PIM3 (0.41) | ALDH1A1DAPK3PRKD3MAP4K4PRKACA | |
| SCHEMBL24276004 | 0.71 | MAPK1 (0.40) | NPSR1ALDH1A1DAPK3PRKD3MAP4K4 | |
| SCHEMBL12612495 | 0.71 | PKM (0.40) | ALDH1A1DAPK3PRKD3MAP4K4PRKACA | |
| SCHEMBL6997732 | 0.71 | SMN1; SMN2 (0.56) | GAAKDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |