Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994179 | 0.90 | MEN1 (0.49) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| SCHEMBL7005474 | 0.89 | MEN1 (0.53) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| SCHEMBL6999112 | 0.86 | MEN1 (0.51) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| SCHEMBL7001014 | 0.85 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| Hydrochloric Acid SCHEMBL7001018 | 0.85 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| SCHEMBL13008386 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| SCHEMBL7003999 | 0.82 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| SCHEMBL331219 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APKMPOLB | |
| SCHEMBL331776 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APOLBKDM4E | |
| SCHEMBL331351 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2APKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |