Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992546 | 0.91 | EGFR (0.45) | SYKPIM1BRAFEGFR | |
| SCHEMBL8314069 | 0.87 | EGFR (0.57) | EGFR | |
| SCHEMBL6997172 | 0.85 | EGFR (0.50) | EGFR | |
| SCHEMBL8317468 | 0.84 | EGFR (0.57) | BRAFEGFR | |
| SCHEMBL8314131 | 0.82 | EGFR (0.53) | EGFR | |
| SCHEMBL6990925 | 0.82 | SYK (0.48) | SYKPIM1BRAFEGFRCTSC | |
| SCHEMBL6995534 | 0.82 | BRAF (0.49) | SYKPIM1BRAFEGFRCTSC | |
| SCHEMBL6996346 | 0.82 | EGFR (0.47) | EGFRERBB2ERBB4 | |
| SCHEMBL6992120 | 0.81 | EGFR (0.70) | EGFRERBB2 | |
| SCHEMBL8312894 | 0.81 | EGFR (0.51) | SYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |