Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 6/20 | 0.40 |
| ▸ | ALPL | P05186 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL8644508 | 0.96 | KDM4E (0.48) | KDM4EKMT2ACA12CA1CA2 | |
| Ethylene SCHEMBL6989724 | 0.80 | CA12 (0.36) | KDM4EKMT2ACA12CA1CA2 | |
| Cyclopropane SCHEMBL6998820 | 0.80 | KDM4E (0.36) | KDM4EKMT2ACA12CA1CA2 | |
| SCHEMBL16831728 | 0.78 | KDM4E (0.46) | KDM4EKMT2ACA12CA1CA2 | |
| SCHEMBL18638475 | 0.78 | KDM4E (0.46) | KDM4EKMT2ACA12CA1CA2 | |
| SCHEMBL16852910 | 0.74 | KDM4E (0.42) | KDM4EKMT2ACA12CA1CA2 | |
| SCHEMBL18186992 | 0.74 | KDM4E (0.42) | KDM4EKMT2ACA12CA1CA2 | |
| SCHEMBL22451369 | 0.74 | CA9 (0.42) | KDM4ECA12CA1CA2CA4 | |
| SCHEMBL18065115 | 0.74 | CYP2A6 (0.47) | KDM4EKMT2ACA12CA1CA2 | |
| SCHEMBL61176 | 0.72 | KEAP1 (0.44) | KDM4EKMT2ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190002454-A1 | NRF2 Regulators | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-03 | — | — | US | disclosed |
| US-20190002454-A1 | NRF2 Regulators | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-03 | — | — | US | disclosed |
| US-10144731-B2 | Nrf2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-12-04 | — | — | US | disclosed |
| US-20160318917-A1 | NRF2 REGULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-11-03 | — | — | US | disclosed |
| US-20160318917-A1 | NRF2 REGULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-11-03 | — | — | US | disclosed |
| US-20160318917-A1 | NRF2 REGULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-11-03 | — | — | US | disclosed |
| CN-105829305-A | NRF2 REGULATORS | 葛兰素史密斯克莱知识产权发展有限公司 | 2016-08-03 | — | — | CN | disclosed |
| WO-2015092713-A1 | NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-06-25 | — | — | WO | disclosed |
| US-6664251-B2 | Serotonin receptor antagonist; treating cardiovascular disorder | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-0686632-B1 | BENZOTHIAZINE DERIVATIVE | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2003-08-06 | — | — | EP | disclosed |
| US-6316442-B1 | TREATMENT OF HEART DISEASE AND CEREBROVASCULAR DISTURBANCES | SUNTORY LIMITED (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6001827-A | Benzothiazine derivative | SUNTORY LIMITED (JP) | 1999-12-14 | — | — | US | disclosed |
| US-5874429-A | ANTIISCHEMIC AGENTS; CEREBROVASCULAR DISORDERS; CIRCULATORY IDSORDERS | SUNTORY LIMITED (JP) | 1999-02-23 | — | — | US | disclosed |
| EP-0686632-A1 | BENZOTHIAZINE DERIVATIVE | SUNTORY LIMITED (JP) | 1995-12-13 | — | — | EP | disclosed |
| US-5035739-A | PLANT GROWTH REGULATORS | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1991-07-30 | — | — | US | disclosed |
| US-4919705-A | PLANT GROWTH REGULATORS | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1990-04-24 | — | — | US | disclosed |
| EP-0305529-A1 | TRIFLUOROMETHANESULFONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING SAME | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1989-03-08 | — | — | EP | disclosed |
| US-4100347-A | ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1978-07-11 | — | — | US | disclosed |
| US-3966716-A | 2H-1,3,2-dioxaborino-[5,4-c]-1,2-benzo-thiazine 6,6-dioxides | WARNER-LAMBERT COMPANY (US) | 1976-06-29 | — | — | US | disclosed |
| US-3937828-A | Substituted pyrano[3,2-c] [1,2]benzothiazine 6,6-dioxides | WARNER-LAMBERT COMPANY (US) | 1976-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002454-A1 | NRF2 Regulators | NFE2L2, KEAP1, NQO1 | KDM4E 1805/4885KMT2A 1623/4885CA12 4870/4885 |
| US-20160318917-A1 | NRF2 REGULATORS | NFE2L2, KEAP1, NQO1 | KDM4E 1805/4885KMT2A 1623/4885CA12 4870/4885 |
| US-10144731-B2 | Nrf2 regulators | NFE2L2, KEAP1, NQO1 | KDM4E 1805/4885KMT2A 1623/4885CA12 4870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.