Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | CYBB | P04839 | 1/20 | 0.48 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.48 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.48 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755137 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL6755136 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL6755138 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL19307963 | 0.86 | POLB (0.58) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL7000067 | 0.83 | NOX1 (0.49) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL6993134 | 0.81 | LMNA (0.60) | SMN1; SMN2POLBLMNAMAPTTP53 | |
| SCHEMBL10651117 | 0.80 | POLB (0.61) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL7004061 | 0.79 | LMNA (0.58) | SMN1; SMN2LMNAMAPTTP53CYBB | |
| SCHEMBL24124964 | 0.78 | POLB (0.63) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL14020823 | 0.78 | POLB (0.63) | SMN1; SMN2POLBHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015437-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |
| EP-1015437-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999012915-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-03-18 | — | — | WO | disclosed |