Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.43 |
| ▸ | CYBB | P04839 | 1/20 | 0.43 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993134 | 0.89 | LMNA (0.60) | LMNAMAPTTP53SMN1; SMN2ADAMTS5 | |
| SCHEMBL7000029 | 0.84 | LMNA (0.45) | LMNAMAPTTP53SMN1; SMN2ADAMTS5 | |
| SCHEMBL5814643 | 0.82 | LMNA (0.55) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL8523594 | 0.80 | LMNA (0.50) | LMNAMAPTTP53SMN1; SMN2ADAMTS5 | |
| SCHEMBL6997145 | 0.79 | SMN1; SMN2 (0.57) | LMNAMAPTTP53SMN1; SMN2NOX1 | |
| SCHEMBL5671154 | 0.76 | HSD17B10 (0.61) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL6999115 | 0.76 | LMNA (0.47) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL5094084 | 0.73 | HTT (0.58) | LMNAMAPTSMN1; SMN2HTTHSD17B10 | |
| SCHEMBL7708360 | 0.71 | ADAMTS5 (0.40) | LMNAMAPTTP53SMN1; SMN2ADAMTS5 | |
| SCHEMBL7000067 | 0.69 | NOX1 (0.49) | LMNAMAPTTP53SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015437-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |
| EP-1015437-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999012915-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-03-18 | — | — | WO | disclosed |