Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7001018 | 0.98 | MEN1 (0.50) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL7005474 | 0.90 | MEN1 (0.53) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL7003999 | 0.89 | MEN1 (0.50) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL4705798 | 0.87 | MEN1 (0.46) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL7001014 | 0.86 | MEN1 (0.50) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL6997732 | 0.86 | SMN1; SMN2 (0.56) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL6994179 | 0.82 | MEN1 (0.49) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL332743 | 0.80 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2MAPTF2 | |
| SCHEMBL333010 | 0.79 | MEN1 (0.38) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL1609142 | 0.77 | MAPT (0.61) | MEN1KMT2APKMMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |