Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005474 | 0.89 | MEN1 (0.53) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL6999112 | 0.86 | MEN1 (0.51) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL6997732 | 0.85 | SMN1; SMN2 (0.56) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7001018 | 0.85 | MEN1 (0.50) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL7003999 | 0.82 | MEN1 (0.50) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL6994179 | 0.81 | MEN1 (0.49) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| SCHEMBL11070595 | 0.78 | MAPT (0.59) | MEN1KMT2APKMMAPTALDH1A1 | |
| SCHEMBL11270696 | 0.75 | MAPT (0.53) | MEN1KMT2APKMMAPTALDH1A1 | |
| SCHEMBL27574855 | 0.74 | SMN1; SMN2 (0.57) | MEN1KMT2APKMSMN1; SMN2MAPT | |
| Iodomethane SCHEMBL3389060 | 0.74 | MEN1 (0.40) | MEN1KMT2APKMSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |