Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994995 | 0.93 | GABRG2 (0.52) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6998547 | 0.85 | GABRG2 (0.48) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6994991 | 0.84 | GABRG2 (0.47) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL7000853 | 0.82 | GABRG2 (0.48) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2658306 | 0.78 | GABRG2 (0.52) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2659167 | 0.77 | GABRG2 (0.43) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6999782 | 0.76 | GABRG2 (0.46) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL2657940 | 0.74 | GABRG2 (0.53) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6996337 | 0.74 | GABRG2 (0.46) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL7000849 | 0.73 | GABRG2 (0.45) | GABRG2GABRB3GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212324-B1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-10-29 | — | — | EP | claimed |
| EP-1212324-B1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-10-29 | — | — | EP | disclosed |
| US-6608062-B1 | Ligands for gamma-aminobutyric acid receptors; treatment and/or prevention of central nervous system disorders, including anxiety | MERCK SHARP & DOHME LTD. | 2003-08-19 | — | — | US | disclosed |