Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418832 | 0.76 | KDM4E (0.55) | KDM4E | |
| SCHEMBL6992985 | 0.74 | HTR1D (0.55) | KDM4EPOLBHTR1A | |
| SCHEMBL7859785 | 0.74 | SLC6A4 (0.72) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL7864995 | 0.74 | SLC6A4 (0.72) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL7481939 | 0.73 | SLC6A4 (0.70) | SLC6A4 | |
| Hydrochloric Acid SCHEMBL8786395 | 0.73 | SLC6A4 (0.70) | SLC6A4 | |
| SCHEMBL7480892 | 0.72 | NOS3 (0.68) | SLC6A4 | |
| SCHEMBL3341152 | 0.72 | SLC6A4 (0.68) | SLC6A4 | |
| SCHEMBL5367487 | 0.72 | SLC6A4 (0.76) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL13323539 | 0.71 | SLC6A4 (1.00) | SLC6A4KDM4ELMNAPOLBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003738-B1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-19 | — | — | EP | disclosed |
| US-6391891-B1 | ANTISEROTONINE AGENT; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS | SMITHKLINE BEECHAM PLC (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-1003738-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007700-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-18 | — | — | WO | disclosed |