Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.51 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992985 | 0.79 | HTR1D (0.55) | KDM4EALDH1A1MAPT | |
| SCHEMBL6997808 | 0.76 | SLC6A4 (0.55) | KDM4E | |
| SCHEMBL6213822 | 0.73 | NOTUM (0.52) | KDM4EALDH1A1HPGDNOTUMCYP11B2 | |
| SCHEMBL7422396 | 0.72 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDNOTUMCYP11B2 | |
| SCHEMBL21469189 | 0.72 | NOTUM (0.58) | KDM4EALDH1A1HPGDNOTUMCYP11B2 | |
| SCHEMBL29803331 | 0.71 | NOTUM (0.60) | KDM4EALDH1A1HPGDNOTUMCYP11B2 | |
| SCHEMBL22462287 | 0.71 | NOTUM (0.60) | KDM4EALDH1A1HPGDNOTUMCYP11B2 | |
| SCHEMBL9832984 | 0.70 | KDM4E (0.50) | KDM4EALDH1A1HPGDNOTUMCYP11B2 | |
| SCHEMBL9832596 | 0.69 | KDM4E (0.52) | KDM4EALDH1A1HPGDNOTUMCYP11B2 | |
| SCHEMBL13059953 | 0.69 | NOTUM (0.57) | KDM4EALDH1A1HPGDNOTUMCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |