Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.56 |
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | IDH2 | P48735 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997218 | 0.88 | BRAF (0.50) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL6993268 | 0.85 | BRAF (0.55) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL8451632 | 0.85 | BRAF (0.52) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL6996275 | 0.84 | EGFR (0.60) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL6996263 | 0.83 | BRAF (0.51) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL6986988 | 0.82 | EGFR (0.72) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL8318987 | 0.77 | CTSC (0.61) | EGFRIDH2HTTERBB2HPGD | |
| SCHEMBL6990280 | 0.77 | EGFR (0.51) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL6994621 | 0.77 | BRAF (0.48) | BRAFEGFRHTTERBB2HPGD | |
| SCHEMBL8316426 | 0.76 | EGFR (0.69) | BRAFEGFRHTTERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |