Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 8/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316210 | 0.89 | EGFR (0.50) | BRAFEGFRABCG2 | |
| SCHEMBL8316205 | 0.89 | EGFR (0.50) | BRAFEGFRABCG2 | |
| SCHEMBL6994621 | 0.87 | BRAF (0.48) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL6990280 | 0.85 | EGFR (0.51) | BRAFEGFRBRD4ERBB2HPGD | |
| SCHEMBL8317520 | 0.84 | EGFR (0.63) | BRAFEGFRABCG2BRD4ERBB2 | |
| SCHEMBL6997891 | 0.83 | BRAF (0.56) | BRAFEGFRABCG2ERBB2HPGD | |
| SCHEMBL6993268 | 0.83 | BRAF (0.55) | BRAFEGFRABCG2ERBB2HPGD | |
| SCHEMBL8451632 | 0.83 | BRAF (0.52) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL6997218 | 0.81 | BRAF (0.50) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL6996275 | 0.81 | EGFR (0.60) | BRAFEGFRERBB2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |