Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 14/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | CARS1 | P49589 | 1/20 | 0.41 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.41 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993268 | 0.91 | BRAF (0.55) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8318037 | 0.89 | EGFR (0.52) | BRAFEGFRERBB2ERBB4FBP1 | |
| SCHEMBL6997891 | 0.85 | BRAF (0.56) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8316279 | 0.84 | EGFR (0.65) | BRAFEGFRERBB2ERBB4HPGD | |
| SCHEMBL7578315 | 0.84 | BRAF (0.45) | BRAFEGFRERBB2ERBB4FBP1 | |
| SCHEMBL6996263 | 0.83 | BRAF (0.51) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL6997218 | 0.82 | BRAF (0.50) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL6996275 | 0.82 | EGFR (0.60) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL6986988 | 0.80 | EGFR (0.72) | BRAFEGFRERBB2ERBB4HPGD | |
| SCHEMBL8319176 | 0.78 | CSNK2A1 (0.53) | BRAFEGFRERBB2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |