Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.61 |
| ▸ | IKBKB | O14920 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 11/20 | 0.52 |
| ▸ | PLK1 | P53350 | 6/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237418 | 0.94 | FYN (0.65) | FYNIKBKBKDRPLK1BRAF | |
| SCHEMBL6998752 | 0.89 | IKBKB (0.58) | FYNIKBKBKDRPLK1KDM4E | |
| SCHEMBL6992464 | 0.89 | KDR (0.65) | FYNIKBKBKDRPLK1KDM4E | |
| SCHEMBL7002121 | 0.87 | FYN (0.66) | FYNIKBKBKDRPLK1BRAF | |
| SCHEMBL7239325 | 0.86 | KDR (0.58) | FYNIKBKBKDRPLK1BRAF | |
| Hydrochloric Acid SCHEMBL7242637 | 0.86 | FYN (0.59) | FYNIKBKBKDRPLK1BRAF | |
| SCHEMBL7234843 | 0.86 | FYN (0.58) | FYNIKBKBKDRPLK1BRAF | |
| SCHEMBL7239483 | 0.85 | KDR (0.68) | FYNIKBKBKDRPLK1 | |
| SCHEMBL7235444 | 0.85 | IKBKB (0.67) | FYNIKBKBKDRPLK1BRAF | |
| Hydrochloric Acid SCHEMBL7516453 | 0.84 | IKBKB (0.66) | FYNIKBKBKDRPLK1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0989985-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998058926-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-30 | — | — | WO | disclosed |