Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 6/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996425 | 0.91 | PGR (0.34) | PTGS2PGRPTGS1NR3C1NR3C2 | |
| SCHEMBL6995774 | 0.90 | PTGS2 (0.36) | PTGS2PGRPTGS1NR3C1NR3C2 | |
| SCHEMBL6999122 | 0.89 | PTGS2 (0.43) | PTGS2PGRPTGS1PDE3BPDE3A | |
| SCHEMBL6998235 | 0.89 | PTGS2 (0.38) | PTGS2PGRPTGS1NR3C1NR3C2 | |
| SCHEMBL6997789 | 0.88 | PTGS2 (0.34) | PTGS2PGRPTGS1 | |
| SCHEMBL7002303 | 0.88 | PGR (0.35) | PTGS2PGRPTGS1NR3C1NR3C2 | |
| SCHEMBL7002491 | 0.88 | PTGS2 (0.38) | PTGS2PGRPTGS1PDE3BPDE3A | |
| SCHEMBL6995275 | 0.86 | PDE3B (0.31) | ARPDE3BPDE3A | |
| SCHEMBL7001117 | 0.86 | PGR (0.34) | PTGS2PGRPTGS1NR3C1NR3C2 | |
| SCHEMBL6996821 | 0.85 | PGR (0.37) | PTGS2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |