Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5208897 | 0.83 | F2 (0.37) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| Trifluoroacetic Acid SCHEMBL5211180 | 0.80 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL6996710 | 0.75 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL5207728 | 0.73 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| Trifluoroacetic Acid SCHEMBL6993585 | 0.73 | — | — | |
| Trifluoroacetic Acid SCHEMBL5209105 | 0.72 | TP53 (0.38) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| Trifluoroacetic Acid SCHEMBL5210737 | 0.70 | F2 (0.38) | PRSS1PKMMAPTKMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL7432339 | 0.70 | LMNA (0.37) | NPC1RAB9ALMNATP53HPGD | |
| Trifluoroacetic Acid SCHEMBL5207907 | 0.70 | MAPT (0.43) | NPC1RAB9ALMNATP53MAPT | |
| Trifluoroacetic Acid SCHEMBL5208466 | 0.69 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343561-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002047762-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |