Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204130 | 0.86 | KDM4E (0.57) | KDM4ELMNAGAAPIM1NUAK1 | |
| SCHEMBL11363863 | 0.80 | KDM4E (0.51) | KDM4ELMNAGAAPIM1NUAK1 | |
| SCHEMBL7002194 | 0.80 | MAOA (0.53) | KDM4EMAOBMAOAGAASMN1; SMN2 | |
| SCHEMBL38661155 | 0.78 | NUAK1 (0.54) | KDM4ELMNAGAASMN1; SMN2PIM1 | |
| SCHEMBL12553463 | 0.74 | MAOA (0.47) | KDM4EMAOBMAOAGAASMN1; SMN2 | |
| SCHEMBL15902735 | 0.73 | KDM4E (0.69) | KDM4ELMNAMAOAGAASMN1; SMN2 | |
| SCHEMBL31619335 | 0.73 | KDM4E (0.69) | KDM4ELMNAMAOAGAASMN1; SMN2 | |
| SCHEMBL12553458 | 0.73 | KDM4E (0.57) | KDM4ELMNAGAAPIM1NUAK1 | |
| SCHEMBL14451818 | 0.72 | KDM4E (0.73) | KDM4ELMNAGAAPIM1ALDH1A1 | |
| Cilinaphthalide A SCHEMBL15932091 | 0.72 | KDM4E (0.61) | KDM4ELMNAMAOBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1241169-B1 | Isoindoloindolone derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-08-27 | — | — | EP | disclosed |
| US-6465660-B1 | PARTICULARLY 2-HYDROXY-8,9-DIMETHOXYISOINDOLO(2,1-A)INDOL-6-ONE AND 2-HYDROXY-8,9-DIMETHOXYISOINDOLO(2,1-A)INDOL-6-ONE; TREATING A DISORDER OF THE MELATONINERGIC SYSTEM | LES LABORATOIRES SERVIER (FR) | 2002-10-15 | — | — | US | disclosed |
| EP-1241169-A1 | Isoindoloindolone derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-09-18 | — | — | EP | disclosed |