Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 4/20 | 0.41 |
| ▸ | CDK8 | P49336 | 4/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041807 | 0.89 | NPSR1 (0.60) | KDM4EALDH1A1POLBRXFP1NPSR1 | |
| SCHEMBL7246718 | 0.77 | MEN1 (0.46) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL7248984 | 0.74 | NPSR1 (0.44) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL6987780 | 0.71 | NPSR1 (0.63) | KDM4EALDH1A1POLBRXFP1NPSR1 | |
| SCHEMBL7041221 | 0.68 | ADORA2A (0.42) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL7243172 | 0.68 | ALDH1A1 (0.40) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL6996404 | 0.68 | NPSR1 (0.58) | KDM4EALDH1A1POLBRXFP1NPSR1 | |
| SCHEMBL12663163 | 0.64 | ALDH1A1 (0.48) | KDM4EALDH1A1POLBRXFP1MEN1 | |
| SCHEMBL6988781 | 0.62 | KDM4E (0.49) | KDM4EALDH1A1POLBRXFP1NPSR1 | |
| SCHEMBL1857463 | 0.62 | NPSR1 (1.00) | KDM4EALDH1A1POLBRXFP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268486-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074823-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | disclosed |