Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA7 | P43166 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002090 | 0.80 | CYP1A2 (0.40) | HSP90AA1TSHRMAPTKDM4EACHE | |
| SCHEMBL6998918 | 0.77 | HSP90AA1 (0.38) | HSP90AA1TSHRMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7002092 | 0.73 | TSHR (0.39) | HSP90AA1TSHRMAPTKDM4EACHE | |
| SCHEMBL31309801 | 0.71 | ACHE (0.41) | HSP90AA1TSHRKDM4EACHEKMT2A | |
| SCHEMBL14195937 | 0.68 | CYP1A2 (0.48) | TSHR | |
| SCHEMBL23382300 | 0.67 | KMT2A (0.40) | TSHRMAPTKDM4EACHEKMT2A | |
| SCHEMBL14593070 | 0.67 | KDM4E (0.40) | TSHRMAPTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL14067651 | 0.66 | TSHR (0.42) | HSP90AA1TSHRKDM4EACHEKMT2A | |
| SCHEMBL9233379 | 0.66 | ALDH1A1 (0.42) | HSP90AA1TSHRMAPTKDM4EACHE | |
| SCHEMBL2585836 | 0.66 | TSHR (0.38) | TSHRMAPTKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |