Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6718185 | 0.98 | PDPK1 (0.57) | PDPK1HTR2ARETACP3HTR2C | |
| SCHEMBL21259170 | 0.91 | PDPK1 (0.55) | PDPK1HTR2ARETHRH1CYP2D6 | |
| SCHEMBL7003542 | 0.86 | HTR2A (0.57) | PDPK1HTR2AHTR2CHRH1 | |
| SCHEMBL20749590 | 0.86 | PDPK1 (0.50) | PDPK1HTR2ARETACP3HTR2C | |
| SCHEMBL21259158 | 0.81 | PDPK1 (0.44) | PDPK1HTR2AHTR2CSLC6A3HRH1 | |
| SCHEMBL6992704 | 0.80 | PDPK1 (0.45) | PDPK1HTR2ARETADRA1AKCNH2 | |
| SCHEMBL14178994 | 0.77 | PDPK1 (0.45) | PDPK1HTR2AHTR2CHTR2BPRCP | |
| SCHEMBL14169940 | 0.77 | PDPK1 (0.45) | PDPK1ACP3HTR2CSLC6A3 | |
| SCHEMBL61508 | 0.74 | PDPK1 (1.00) | PDPK1HTR2AHTR2CSLC6A3HRH1 | |
| SCHEMBL61509 | 0.74 | PDPK1 (1.00) | PDPK1HTR2AHTR2CSLC6A3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |