Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001701 | 0.88 | HDAC1 (0.36) | PDPK1OPRL1KCNH2FNTAFNTB | |
| SCHEMBL6997518 | 0.87 | HTR2A (0.44) | PDPK1HTR2AADRA1A | |
| SCHEMBL6998985 | 0.80 | PDPK1 (0.59) | PDPK1KCNH2RETHTR2AADRA1A | |
| Hydrochloric Acid SCHEMBL6718185 | 0.79 | PDPK1 (0.57) | PDPK1RETHTR2A | |
| SCHEMBL8355428 | 0.78 | HTR2A (0.39) | PDPK1OPRL1KCNH2FNTAFNTB | |
| SCHEMBL22193900 | 0.78 | HTR2A (0.39) | PDPK1OPRL1KCNH2FNTAFNTB | |
| SCHEMBL12050760 | 0.78 | FNTA (0.45) | OPRL1KCNH2FNTAFNTBRET | |
| SCHEMBL4969358 | 0.76 | FNTA (0.41) | OPRL1KCNH2FNTAFNTBP2RX7 | |
| SCHEMBL16559388 | 0.75 | SLC6A2 (0.39) | PDPK1OPRL1KCNH2FNTAFNTB | |
| SCHEMBL22193783 | 0.75 | RET (0.39) | OPRL1KCNH2FNTAFNTBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |