Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2541634 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL29219910 | 0.86 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL257112 | 0.83 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL10261585 | 0.83 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL5856909 | 0.83 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL17485847 | 0.81 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL4140284 | 0.81 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL3974470 | 0.79 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HPGDCYP3A4KMT2A | |
| SCHEMBL19220827 | 0.79 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HPGDCYP3A4NOTUM | |
| SCHEMBL19940614 | 0.78 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HPGDCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920425-B1 | SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2003-02-19 | — | — | EP | disclosed |
| CN-1098264-C | Substituted 4- (1H-benzimidazol-2-yl-amino) piperidines for the treatment of allergic diseases | AVENTIS PHARMA INC (US) | 2003-01-08 | — | — | CN | disclosed |
| US-6211199-B1 | HISTAMINE AND TACHYKININ RECEPTOR ANTAGONISTS; ANTIASTHMATICS, ANTIEMETICS; RESPIRATORY SYSTEM DISORDERS, INFLAMMATORY BOWEL DISEASE, CONJUNCTIVITIS | AVENTIS PHARMACEUTICALS INC. | 2001-04-03 | — | — | US | disclosed |
| EP-0920425-A1 | SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-06-09 | — | — | EP | disclosed |
| CN-1202894-A | Substituted 4-(1H-benzimidzol-2-yl-amino) piepridines useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL INC (US) | 1998-12-23 | — | — | CN | disclosed |
| WO-1997019074-A1 | SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-05-29 | — | — | WO | disclosed |