Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | PLK1 | P53350 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991975 | 0.89 | FYN (0.62) | FYNFGFR1IGF1RKDRPLK1 | |
| Hydrochloric Acid SCHEMBL6997490 | 0.84 | FYN (0.59) | FYNKDRPLK1BRD4CDK2 | |
| SCHEMBL7232580 | 0.81 | KDR (0.63) | FYNIGF1RKDRPLK1AURKA | |
| SCHEMBL7231388 | 0.81 | FYN (0.61) | FYNIGF1RKDRPLK1CDK2 | |
| SCHEMBL7241122 | 0.80 | FYN (0.65) | FYNFGFR1IGF1RKDRPLK1 | |
| SCHEMBL7235943 | 0.79 | FYN (0.56) | FYNIGF1RKDRPLK1ZAP70 | |
| SCHEMBL7235872 | 0.78 | FYN (0.59) | FYNIGF1RKDRPLK1IKBKB | |
| SCHEMBL7233573 | 0.78 | FYN (0.57) | FYNIGF1RKDRPLK1CDK2 | |
| Hydrochloric Acid SCHEMBL6998665 | 0.78 | FYN (0.59) | FYNIGF1RKDRPLK1BRD4 | |
| Hydrochloric Acid SCHEMBL7232574 | 0.78 | PLK1 (0.64) | FYNIGF1RKDRPLK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |