Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.62 |
| ▸ | BRD4 | O60885 | 5/20 | 0.54 |
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | BUB1 | O43683 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | STK16 | O75716 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | LATS1 | O95835 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6997490 | 0.90 | FYN (0.59) | FYNBRD4CDK2AURKACDK4 | |
| SCHEMBL6999470 | 0.89 | FYN (0.60) | FYNBRD4CDK2AURKACDK4 | |
| SCHEMBL7003522 | 0.86 | FYN (0.55) | FYNCDK2AURKACDK4CCNA2 | |
| Hydrochloric Acid SCHEMBL7093809 | 0.85 | BRD4 (0.57) | FYNBRD4CDK2AURKACDK4 | |
| SCHEMBL7231388 | 0.85 | FYN (0.61) | FYNCDK2CCNA2EGFRPLK1 | |
| SCHEMBL7232580 | 0.85 | KDR (0.63) | FYNAURKAEGFRPLK1KDR | |
| SCHEMBL6999593 | 0.84 | FYN (0.55) | FYNCDK2AURKACDK4CCNA2 | |
| SCHEMBL7235872 | 0.81 | FYN (0.59) | FYNEGFRPLK1KDRIGF1R | |
| SCHEMBL7233573 | 0.81 | FYN (0.57) | FYNCDK2AURKACCNA2EGFR | |
| SCHEMBL7241122 | 0.81 | FYN (0.65) | FYNAURKAABL1NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | claimed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | claimed |
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |