Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.37 |
| ▸ | PGR | P06401 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000159 | 0.89 | PTGS2 (0.43) | PTGS2PTGS1PGRKIF11 | |
| SCHEMBL6999947 | 0.87 | PTGS2 (0.45) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6999052 | 0.84 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL6995368 | 0.83 | PGR (0.38) | PTGS2PTGS1PGRPIK3CDPIK3CA | |
| SCHEMBL6995143 | 0.79 | PGR (0.36) | PTGS2PGR | |
| SCHEMBL6996821 | 0.78 | PGR (0.37) | PTGS2PGR | |
| SCHEMBL6998609 | 0.78 | PTGS2 (0.43) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7002352 | 0.77 | PTGS2 (0.45) | PTGS2PTGS1PGREPAS1 | |
| SCHEMBL6997576 | 0.77 | PTGS2 (0.53) | PTGS2PTGS1PGR | |
| SCHEMBL3228803 | 0.76 | PTGS2 (0.44) | PTGS2PTGS1PGRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |