Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858394 | 0.93 | PLK1 (0.45) | MAPTTP53POLBL3MBTL1PLK1 | |
| SCHEMBL6850115 | 0.85 | PLK1 (0.48) | MAPTL3MBTL1PLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6854923 | 0.81 | PLK1 (0.43) | MAPTTP53L3MBTL1PLK1ALDH1A1 | |
| SCHEMBL6849994 | 0.81 | PLK1 (0.48) | MAPTTP53L3MBTL1PLK1ALDH1A1 | |
| SCHEMBL6791485 | 0.80 | ALDH1A1 (0.54) | MAPTTP53L3MBTL1PLK1ALDH1A1 | |
| SCHEMBL6857080 | 0.79 | PLK1 (0.52) | MAPTTP53L3MBTL1PLK1ALDH1A1 | |
| SCHEMBL6854926 | 0.79 | PLK1 (0.46) | MAPTTP53L3MBTL1PLK1ALDH1A1 | |
| SCHEMBL6855586 | 0.78 | PLK1 (0.50) | MAPTL3MBTL1PLK1ALDH1A1HTT | |
| SCHEMBL6850183 | 0.76 | PLK1 (0.49) | MAPTTP53L3MBTL1PLK1ALDH1A1 | |
| SCHEMBL6854083 | 0.76 | PLK1 (0.47) | MAPTTP53L3MBTL1PLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |