Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27010071 | 0.76 | NOTUM (0.55) | NOTUMDRD2DRD1DRD5DRD3 | |
| SCHEMBL7001566 | 0.75 | NOTUM (0.46) | NOTUMDRD2DRD1DRD5DRD3 | |
| SCHEMBL7002593 | 0.74 | SLC6A2 (0.48) | NOTUMDRD2DRD1DRD5DRD3 | |
| SCHEMBL2073396 | 0.73 | SLC6A2 (0.47) | NOTUMDRD3HTR1AHTR2CHTR2B | |
| SCHEMBL3293816 | 0.70 | NPSR1 (0.47) | NOTUMALDH1A1LMNA | |
| SCHEMBL24317347 | 0.68 | NOTUM (0.49) | NOTUMDRD2DRD1DRD5DRD3 | |
| SCHEMBL2625801 | 0.68 | NOTUM (0.59) | NOTUMDRD2DRD1DRD5DRD3 | |
| SCHEMBL7948766 | 0.68 | SIGMAR1 (0.47) | NOTUMHTR1A | |
| SCHEMBL20905152 | 0.67 | NOTUM (0.70) | NOTUMDRD2ALDH1A1 | |
| SCHEMBL11304976 | 0.66 | HTR6 (0.62) | NOTUMDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140943-B1 | SUBSTITUTED PYRROLOINDOLES | LILLY CO ELI (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6448284-B1 | PYRROLO(1,2-A)INDOLES; INHIBITING NONPANCREATIC SECRETORY PHOSPHOLIPASE A2 MEDIATED RELEASE OF FATTY ACIDS; SEPTIC SHOCK | ELI LILLY AND COMPANY | 2002-09-10 | — | — | US | disclosed |
| EP-1140943-A2 | SUBSTITUTED PYRROLOINDOLES | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037472-A2 | SUBSTITUTED PIRROLOINDOLES | ELI LILLY AND COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |