Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 19/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996240 | 0.84 | PRKCQ (0.57) | PRKCQPRKCDLYNPRKCHPRKCE | |
| SCHEMBL6382258 | 0.80 | EGFR (0.47) | EGFR | |
| SCHEMBL6383964 | 0.80 | MAP3K8 (0.47) | EGFR | |
| SCHEMBL6379765 | 0.80 | EGFR (0.57) | EGFR | |
| SCHEMBL4450721 | 0.80 | EGFR (0.62) | PRKCQPRKCDLYNPRKCHPRKCE | |
| SCHEMBL5888336 | 0.79 | MAP2K1 (0.52) | EGFR | |
| SCHEMBL6382153 | 0.79 | EGFR (0.50) | EGFR | |
| SCHEMBL6381724 | 0.79 | EGFR (0.47) | EGFR | |
| SCHEMBL6384102 | 0.79 | EGFR (0.58) | PRKCQEGFR | |
| SCHEMBL6384067 | 0.79 | EGFR (0.58) | PRKCQEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |