SCHEMBL6999750

SCHEMBL6999750

CN1CCC(c2csc3ccc(NC(=O)Nc4ccc(-c5ccncc5)c(Cl)c4)cc23)CC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 3/20 0.41
HTR1D P28221 10/20 0.40
HTR1B P28222 10/20 0.40
HTR1A P08908 1/20 0.40
HTR1F P30939 1/20 0.40
MALT1 Q9UDY8 1/20 0.39
MEN1 O00255 2/20 0.39
LMNA P02545 2/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
GAA P10253 1/20 0.39
DNMT1 P26358 1/20 0.39
HTT P42858 1/20 0.39
DUSP3 P51452 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
MCL1 Q07820 1/20 0.39
WRN Q14191 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6993724 0.87 HTR1D (0.44) HTR1DHTR1BHTR1AHTR1FGAA
SCHEMBL8111275 0.84 IDO1 (0.49) HTR1DHTR1BHTR1AHTR1FMALT1
SCHEMBL7000915 0.83 HTR1D (0.62) BLMHTR1DHTR1BHTR1AHTR1F
SCHEMBL6994397 0.79 BLM (0.39) BLMMALT1MEN1LMNAKMT2A
SCHEMBL8589728 0.76 HSP90AA1 (0.43) BLMMEN1LMNAKMT2AKDM4E
SCHEMBL8588714 0.74 HSP90AA1 (0.42) BLMMEN1LMNAKMT2AKDM4E
SCHEMBL6999186 0.74 HTR1D (0.58) BLMHTR1DHTR1BHTR1AHTR1F
SCHEMBL6999683 0.73 HTR1D (0.63) BLMHTR1DHTR1BHTR1AHTR1F
SCHEMBL8111234 0.73 MALT1 (0.51) HTR1DHTR1BHTR1AMALT1LMNA
SCHEMBL7001841 0.71 HTR1D (0.59) HTR1DHTR1BHTR1AHTR1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1003738-B1 BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 2003-11-19 EP claimed
US-6391891-B1 ANTISEROTONINE AGENT; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS SMITHKLINE BEECHAM PLC (GB) 2002-05-21 US claimed
EP-1003738-A1 BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 2000-05-31 EP claimed
WO-1999007700-A1 BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 1999-02-18 WO claimed
EP-1003738-B1 BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 2003-11-19 EP disclosed
US-6391891-B1 ANTISEROTONINE AGENT; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS SMITHKLINE BEECHAM PLC (GB) 2002-05-21 US disclosed
EP-1003738-A1 BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 2000-05-31 EP disclosed
WO-1999007700-A1 BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS SMITHKLINE BEECHAM PLC (GB) 1999-02-18 WO disclosed