Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 8/20 | 0.44 |
| ▸ | HTR1B | P28222 | 8/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999750 | 0.87 | BLM (0.41) | HTR1DHTR1BHTR1AMAPTHTR1F | |
| SCHEMBL6999514 | 0.84 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8130310 | 0.84 | HTR1A (0.44) | HTR1DHTR1BHTR1AMAPTHTR2C | |
| SCHEMBL6994311 | 0.80 | ERN1 (0.43) | HTR1DHTR1BHTR1AMAPTHTR2C | |
| SCHEMBL8116944 | 0.75 | KDR (0.38) | HTR1DHTR1BHTR1AMAPTHTR2C | |
| SCHEMBL8119592 | 0.74 | HTR1A (0.67) | HTR1DHTR1BHTR1AMAPTHTR2C | |
| SCHEMBL6999186 | 0.73 | HTR1D (0.58) | HTR1DHTR1BHTR1AMAPTHTR1F | |
| SCHEMBL8136744 | 0.73 | HTR1D (0.56) | HTR1DHTR1BHTR1AMAPTHTR2C | |
| SCHEMBL8703019 | 0.71 | DRD2 (0.53) | DRD2SLC6A4RAB9ANPC1 | |
| SCHEMBL8551605 | 0.71 | DRD2 (0.56) | DRD2SLC6A4NPSR1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003738-B1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-19 | — | — | EP | claimed |
| US-6391891-B1 | ANTISEROTONINE AGENT; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS | SMITHKLINE BEECHAM PLC (GB) | 2002-05-21 | — | — | US | claimed |
| EP-1003738-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | claimed |
| WO-1999007700-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-18 | — | — | WO | claimed |
| EP-1003738-B1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-19 | — | — | EP | disclosed |
| US-6391891-B1 | ANTISEROTONINE AGENT; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS | SMITHKLINE BEECHAM PLC (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-1003738-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007700-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-18 | — | — | WO | disclosed |