Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.56 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000014 | 0.92 | CCR2 (0.56) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL7855473 | 0.90 | CCR2 (0.54) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL6300925 | 0.89 | CCR2 (0.71) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL6302602 | 0.88 | CCR2 (0.57) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL6596933 | 0.86 | CCR2 (0.57) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL6306975 | 0.86 | CCR2 (0.72) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL6303484 | 0.86 | CCR2 (0.72) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL7002453 | 0.85 | CCR2 (0.62) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL6359062 | 0.85 | CCR2 (0.52) | CCR2NOD2NOD1MAPTLMNA | |
| SCHEMBL7000463 | 0.84 | CCR2 (0.55) | CCR2NOD2NOD1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150953-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| US-6613760-B1 | Compounds such as N-(3,4-Dichlorobenzyl)-2-ethoxycarbonyl-indole-4-carboxylic acid, used as inhibitors of monocyte chemoattractant proteins (MCP-1) and RANTES induced chemotaxis; antiinflammatory agents | ASTRAZENECA AB (SE) | 2003-09-02 | — | — | US | disclosed |
| EP-1150953-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046197-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |